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Resveratrol inhibits glioblastoma cells and chemoresistance progression through blockade P-glycoprotein and targeting AKT/PTEN signaling pathway

Pharmacological resistance of PRL-secreting tumors is generally defined as failure to normalize PRL levels, and to achieve tumor size reduction of at least 50%, although this definition is still controversial and a variety of definitions of DA-resistance have been used (15, 18)

PMID: 27227540, PMCID: PMC4882051, PII: PONE-D-15-55618, DOI: 10.1371/journal.pone.0156387, ISSN: 1932-6203

Paclitaxel was not included in the set of 68 drugs evaluated in the Sharlow et al

Research question formulation The research question (RQ) of this study was formulated using the PICO (Population, Intervention, Comparison, Outcomes) framework