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Relevant articles were selected by classifying the title, abstract, and full text of all the studies and limiting the included studies to those published in English

The main factors that contribute to the systemic character of HF are neuroendocrine activation, inflammation, and alterations in metabolism [33]

Exosomes are small EVs that transport cytosolic biomolecules, such as miRNAs and proteins, from virtually all cells in the body to neighboring and distal cells via the endocytic pathway