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In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]

Rowe PC, Underhill RA, Friedman KJ, Gurwitt A, Medow MS, Schwartz MS, et al

So the conversion is very important. His lab targeted the hippocampus area of the brain, where testosterone acts through whats known as the MAPK pathway to induce its antidepressant and anti-anxiety effects

Therefore, most experts recommend decreasing the intake of sodium chloride (salt) while simultaneously increasing the intake of potassium