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A prospective study of the association between physical activity and risk of prostate cancer defined by clinical features and TMPRSS2:ERG

5 BenezechC.DoudementM.GourionB

This causes DNA damage and formation of ONOO due to excess NO (nitrosative stress) and other free radicals

Homocysteine, through activation of NMDA receptors, induces Ca +2 , leading to excitotoxicity, astrocyte activation with release inflammatory mediators, and matrix metalloproteinase (MMP) activation with subsequent BBB injury and microvascular inflammation (Kamat et al