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At present, several studies have found that GLP-1 analog Lira may improve lipid metabolism and fat deposition by downregulating the expression of lipid metabolism-related genes FAS, and ACC-a mRNA, or promoting the expression of PI3K protein in mouse liver

10.1016/j.tranon.2021.101314 66 XuM.ZhangD.YanJ

and pregnancy-specific liver diseases included HELLP syndrome, intrahepatic cholestasis of pregnancy, and acute fatty liver of pregnancy

According to the equation, when the denominator (plasma concentration) is very small relative to the numerator (total amount of drug in the body), the resulting Vd must be very large to maintain the mathematical relationship

In OA research, recent evidence indicates that pharmacological activation of the Nrf2GPX4 signaling axis using bioactive natural products or synthetic small molecule agonists can effectively mitigate ferroptosis in vitro cultured chondrocytes and in vivo OA animal models, while significantly suppressing ECM degradation progression (Wu et al., 2025b