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Front Endocrinol (Lausanne) (2016) 7:131

Chromium Enhances the action of insulin and is used in the prevention and treatment of Type 2 Diabetes

Allergic reactions to any of the ingredients are possible, though relatively uncommon given the natural origin of the primary components

While it is marketed as an effective non-invasive fat reduction method, there are concerns about its safety and a lack of clinical evidence supporting its efficacy, especially when compared to more established alternatives like ultrasound-based treatments such as ULTRAcel Q+

Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity (Hirayama et al., 2020)