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384 The WMS 2024 guidelines recommend 30 mg every 12 h, which was initiated 24 h prior to ascending and continued until either descent begins

Ma Y, Erb ML, Moore DJ (2025) Aging, cellular senescence and Parkinsons disease

This is especially true if the medication has been given in higher doses or too soon before bedtime

Montalban X, Vermersch P, Arnold DL, Bar-Or A, Cree BAC, Cross AH, Kubala Havrdova E, Kappos L, Stuve O, Wiendl H, Wolinsky JS, Dahlke F, Le Bolay C, Shen Loo L, Gopalakrishnan S, Hyvert Y, Javor A, Guehring H, Tenenbaum N, Tomic D (2024) Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials

Rivera-Chvez F, Zhang LF, Faber F et al (2016) Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella