Vol. XVIII · Free shipping $75+ · Read the collection
Feature · Product Review
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Description

This hardwired regulatory mechanism together with the observation that only the simultaneous depletion of these three FOXO isoforms results in a cancer phenotype in mice [32, 113] clearly points to redundant tumor suppressor functions of these proteins in cancer

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The conformational preferences were determined experimentally using either the cysteine accessibility experiments or by comparing binding affinity to specific mutants that shift the conformational state

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