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doi: 10.1111/bjd.15151

Disclosures: Yash Hegde: Nothing to Disclose, Adnan Said: Mallinckrodt: Speaking and Teaching 909 SOCIAL ISOLATION IS HIGHER AMONG PEOPLE WITH CHRONIC LIVER DISEASE AND ASSOCIATED WITH INCREASED PYSCHOLOGICAL DISTRESS AND ALL-CAUSE MORTALITY Tiana Walker 1 Alysa Alejandro-Soto 1 Lauren Nephew 2 Patricia Jones 3 Nneka Ufere 1 Carlos Lago Hernandez 4 , 1 Massachusetts General Hospital, 2 Indiana University, 3 University of North Carolina at Chapel Hill, 4 University California San Diego Background: Social isolation has been identified as an important national public health concern

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Pajarillo et al., 2020a), suggesting that impairing REST signals in neural cells might be involved in Mn toxicity mechanisms