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formation of bone, synthesis of hemoglobin, nervous system to maintain the myelin sheet, and co-factor for several enzymes such as dopamine hydroxylase, superoxide dismutase, cytochrome oxidase, tyrosinase and ferroxidase 17,18,19

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For individual EV, there is no switch between anti-inflammatory and pro-inflammatory effects

Abdominal swelling may be an early sign of this syndrome