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2024;134(24):e170953

An intriguing hypothetical answer is that activation of a latent viral infection leads to lysis and thereby exposure of the nuclear antigens to detection by the immune system, as is the case for varicella-zoster virus [54, 55, 6769]

Bresell, A

Its often a downstream consequence of inflammation and energy collapse , especially in the context of chronic infections, toxic exposures, and persistent immune activation