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Another clinical trial (NCT00395655) reported the utilization of demethylating agent hydralazine along with valproic acid plus neoadjuvant cyclophosphamide and doxorubicin therapy in locally advanced breast cancer patients

The intestine facilitates material exchange with luminal contents through specialized pathwaysnotably the paracellular pathway, which typically permits the passage of molecules larger than 15 (approximately 3.5 kDa) (51)

doi: 10.1016/j.fct.2018.02.013 79 ZhangSXuNNieJDongLLiJTongJ

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Loss of DNA methylation in the CDH3 gene promoter results in the overexpression of P-cadherin in colorectal and breast carcinomas, which decreased cell polarity and promotes the invasion and migration of colorectal and breast cancer cells (Paredes et al., 2005