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Vitamin B12, also known as cobalamin, is an important water-soluble vitamin involved in red blood cell production, brain health and DNA synthesis

NAD+ shuttles electrons in glycolysis, the TCA cycle and oxidative phosphorylation, making it essential to mitochondrial energy production

Thiamine, pyridoxine and cyanocobalamin have particular importance for the metabolism in the peripheral and central nervous system

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Supplements which are generally considered safe can have side effects in large doses, or when the upper limit is exceeded, especially when that nutrient can be stored in the body