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Iron-sulfur clusters: from metals through mitochondria biogenesis to disease

Generation of CRISPR KO strains To generate a knockout of glutathione reductase (GSR) in HEK293 cells, a guide RNA sequence targeting exon 1 was cloned into the pSpCas9(BB)-2A-GFP (PX458) vector, gifted from Feng Zhang (Addgene plasmid #48138, Watertown, MA, United States) [75]

Many attempts have been made to explore the possibility that SLC1A5 suppression via small molecules might exert anticancer effects

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Some symptom worsening may reflect medication side effects, coinfections, autonomic dysfunction, or unrelated illness