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Focused low-intensity pulsed ultrasound promotes autophagosome-lysosome fusion via the phosphoglycerate mutase family member 5 (PGAM5)/FUN14 domain containing 1 (FUNDC1) pathway, increasing the LC3-II/LC3-I ratio in chondrocytes (104)

If there is no clear clinical improvement within 2-3 weeks, second-line options such as RTX or CP should be initiated immediately

On the other hand, mice depleted of dopamine have a complete suppression of REM sleep

nevertheless, there is still a dearth of solid human clinical evidence

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