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The catechol O-methyltransferase inhibitor entacapone in the treatment of Parkinsons disease: personal reflections on a first-in-class drug development programme 40 years on

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Bacterial colonization assay Animals were treated under behavioral assay condition with indicated bacterial mutants for 12 hours, picked into tubes with M9 buffers, washed three times, and placed on empty NGM plates containing 100g/mL carbenicillin for 1 hour