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Unfortunately, at present, no more effective measures can completely alleviate or reverse tissue fibrosis, so symptomatic treatments for fibrosis-related symptoms are commonly adopted, like non-steroidal anti-inflammatory drugs (NSAIDs) for muscular pain, injection of botulinum toxin for dystonia, and oxygen therapy or mechanical ventilation for respiratory failure

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It has been reported that BH4 supplementation can restore NO and reduce animal myocardial fibrosis (96)