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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

The most critical aspect of apathy is the decrease of motivation, and several behavioral assays have been proposed to measure the degree of motivation, for example, the progressive ratio task (Spangenberg and Wichman, 2018), the Switchmaze test (Hartmann et al., 2024), foraging arena test (Xeni et al., 2024) or vision depended behavior (Ortiz et al., 2020)

Potential side effects are minimal in studies, but include mild gastrointestinal issues

DOI: 10.1016/j.jpsychires.2013.11.011 64

Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-B pathway