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doi: 10.1038/nm0398-291 219 McNamaraN

Pathogenic tau can seed synaptically connected cells and lead to the stimulation and aggregation of natively folded tau in naive cells, leading to further progression of the disease ( A laboratory study conducted on transgenic mice expressing human non-mutant tau was used to assess the impact of the post-translational hyper-phosphorylation of tau on the central and peripheral nervous system after a period of 3 and 6 months ( PET imaging studies on Alzheimers disease have shown that cognition has a better correlation with tau pathology than with A-plaque deposition (Shaw et al., 2009

Zhang, L.J

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Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile