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Science (New York, NY) 351 , 728733 (2016)

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Your GP or prescriber should be informed of: All current medicines , including over-the-counter supplements and herbal remedies, to assess potential interactions particularly for medicines with a narrow therapeutic index Any history of liver, kidney, gastrointestinal, or pancreatic conditions , which may influence the safety of lipotropic agents or GLP-1-based therapies Diabetes or pre-diabetes , given the glucose-modulating effects of retatrutide Previous adverse reactions to injectable preparations or weight management treatments The following groups should not use retatrutide or Lipo C injections outside approved clinical trials, and should discuss their options carefully with a clinician: People who are pregnant, breastfeeding, or planning to conceive Adolescents and young people under 18 years of age People with significant hepatic or renal impairment If you are approached by a private clinic offering retatrutide or Lipo C injections, ask for full documentation of the product's regulatory status, the prescriber's qualifications, and the clinical rationale for the proposed treatment plan