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Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by Hsp90 inhibition

May 1 2022;29(5):537-544

and elevated 4-HNE levels found in both cartilage and synovial fluid of surgically induced canine OA models, where direct intra-articular injection of 4-HNE could replicate the cartilage destruction phenotype, accompanied by significant upregulation of MMP13, ADAMTS5, and cyclooxygenase-2 (COX2) expression (Shi et al., 2014)