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WD: Data curation, Methodology, Project administration, Resources, Supervision, Validation, Writing review and editing

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Direct ROS generation at the nano-nio interface (primary oxidative stress) This route exemplifies the double-edged sword of nanotechnology: the very reactivity that makes ENMs attractive for catalysis, remediation, and antimicrobial action is transposed into toxicological liability upon biological exposure

Conclusion: In our study, NAC did not seem to affect length of hospitalization nor 90-day mortality in patients with AH