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Suitable candidates Adults with stable body weight, ideally within 15% of their healthy weight range BMI generally 30 (some practitioners extend to 35 for specific indications) Localised adiposity at the target site, distinct from overall body fat distribution Good to adequate skin elasticity at the treatment area Realistic expectations established clearly during consultation No active skin conditions, infection or inflammation at the treatment area Contraindications Pregnancy or breastfeeding Lipodystrophy Severe hepatic or renal impairment Active infection at the treatment area defer until resolved Known hypersensitivity to any product component Anticoagulant therapy or bleeding disorder assess individually Clinical communication point: The distinction between contouring and weight loss must be established in writing at consultation

noradrenaline References: Biaggioni I (2021): Adrenoceptor Agonists & Sympathomimetic Drugs (Chapter 9)

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Once reconstituted, the solution is sensitive to temperature and must be stored at 2-8C

It has been shown, for example, that the activation of NF-B by a variety of agents can be blocked by NAC, suggesting that the production of ROS may act as a common pathway for a diverse range of stimuli [13, 14, 54, 55, 58, 62, 101, 103, 114116]