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Water-soluble tomato extract, a polyphenol-rich natural product, was used in a randomized, double-blind, placebo-controlled trial of overweight and obese adults in which 22 subjects received 2 150 mg of Fruitflow or placebo (maltodextrin) daily for 4 weeks, with 6 weeks between interventions

Trends Cell Biol 30(9):720735 Horton ER, Humphries JD, James J, Jones MC, Askari JA, Humphries MJ (2016) The integrin adhesome network at a glance

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Effects of glutamine metabolism on immune response Metabolic reprogramming of glutamine metabolism in tumor cells and its impact on immune response Glutamine metabolism maintains tumor survival and progression, and is very important for multiple biological processes such as nucleotide synthesis, amino acid production, protein glycosylation modification, extracellular matrix production, epigenetic modifications, maintenance of cellular redox balance, and autophagy [68]

These chemical or physical modifications of small molecule ferroptosis modulators improve their bioavailability and targeting, and significantly increase their clinical application potential