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4 Strengths and limitations This review integrates evidence across cellular, organ, and physiological levels, highlighting autophagy pathways, hormonal regulation involving GH, cortisol, insulin, leptin, and thyroid hormones, as well as cardiovascular, neurological, and gastrointestinal outcomes

Hypertrophy of the intima and media, sclerosis of the vascular wall, and the formation of atheromatous plaques are structural changes in the renal vessels due to aging, similar to the changes observed in vessels in other organs of the body

Confirm inflammation is trending down and copper levels remain in range

Systemic inflammation has been linked to impaired cognitive function and aberrations in brain structure in many settings (refer to the Age-Related Cognitive Decline protocol for a more thorough discussion of the role of inflammation in cognitive dysfunction)