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Specifically, AXL activation 73,74 , NOTCH3-dependent activation of the -catenin signalling pathway 75 , activation of insulin-like growth factor 1 receptor (IGF1R) through KDM5 or forkhead box protein A1 (refs

The underlying reason maybe that it doesnt work directly on the brain but through a systematic response

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Researchers have identified elevated levels of ATF4 expression in GS-deficient cells, which has been shown to result in increased expression of aminoacyl-tRNA synthetase (ARS) [214]

Hickmann FH, Cecatto C, Kleemann D et al (2015) Uncoupling, metabolic inhibition and induction of mitochondrial permeability transition in rat liver mitochondria caused by the major long-chain hydroxyl monocarboxylic fatty acids accumulating in LCHAD deficiency