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When an ischemic stroke occurs, the lack of blood and glucose leads to insufficient energy supply, causing the death of neurons in the infarcted brain area

coli strain Rosetta (DE3) (Novagen)

72 These astrocytes maintain their interactions with local neurones, synapses, oligodendrocytes and vascular cells but may alter these interactions in accordance with context-specific reactive changes in molecular expression and functions

Additionally, Fer-1, an effective lipid peroxidation inhibitor, can inhibit ferroptosis-related changes in erastin-treated keratinocytes and block inflammation both in vitro and in vivo, reducing cytokine production, and alleviating psoriasiform dermatitis in the imiquimod-induced model [207]

Research further integrates organoid drug screening with multi-omics technologies, systematically analyzing the mechanisms of drug action via transcriptome sequencing and proteomics analysis of drug-treated organoid samples (Toshimitsu et al., 2022