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subtilis rib operon consists of five genes, ribDG, ribE, ribAB, ribH, ribT , forming one transcription unit (mRNA), and contains the regulatory region ribO , untranslated leader region, that is located with the major promoter P1 (transcription start) upstream of the first structural gene in the operon (Figure 2) (Sklyarova et al., 2012)

GPX4 has been reported to be overexpressed in cancer tissues compared to normal tissues and to be associated with low levels of DNA methylation and enrichment of H3K4me3 and H3K27ac marks at its promoter, suggesting that epigenetic regulation may be involved in its aberrant overexpression[22]

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