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Administration of ART in HIV management has been shown to induce oxidative stress in patients, however, ART induced oxidative stress is minimal, compared to the level of ROS generated by the viral infection in patients [1921]

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The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study