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Under inflammatory conditions, pro-inflammatory cytokines [e.g., interferon-gamma (IFN-)] can activate IDO1, diverting Trp metabolism toward the kynurenine (KYN) pathway while inhibiting 5-HT synthesis, resulting in serotonin depletion and exacerbation of neurotransmitter imbalance (Rus et al., 2015)

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azathioprine, 6-mercaptopurine or in rare cases tioguanine)

Livdans-Forret AB, Harvey PJ, Larkin-Thier SM

Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter