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Moreover, it was also demonstrated that WFS1 regulates secretory granule acidification in -cells and neurons (Sutt et al., 2015) and that the ER dysfunction caused by WFS1 deficiency is accompanied by altered mitochondrial function in -cells and neurons contributing to diabetes and neurodegeneration (Maxwell et al., 2020)

Furthermore, viral protein nsp5 and nsp14 interact with host redox-enzymes: glutathione peroxidase (GPx) and peroxiredoxin (Prx), in both cytoplasm and mitochondria to dysregulate redox balance in different cellular compartments and enhance SARS-CoV-2 infection 21

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Saueressig T, Owen PJ, Pedder H, Tagliaferri S, Kaczorowski S, Altrichter A, et al