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Our findings demonstrate that this mucoadhesive, nano-enabled system successfully overcomes the primary bottleneck of conventional therapies (the blood-brain barrier) leading to significantly enhanced neuro-restoration, reduced oxidative stress, and suppressed neuroinflammation in a PD model

Drug-resistant exosome miR-99b-3p induces macrophage polarization and confers chemoresistance on sensitive cells by targeting PPP2CA

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lupulina further confirms metal-induced ET pathway plasticity, with Cu + activating multiple ACO genes and ET-;response regulators (EIN3/EIL1) ( Figure 1