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Elevated Gal-3 levels have been observed in PLWH compared to uninfected controls, suggesting ongoing myocardial fibrosis and inflammation ( 3.5 Cardiac electrophysiological risks in HIV-associated cardiomyopathy Importantly, PLWH are also at increased risk for electrophysiological abnormalities, including QT interval prolongation and Brugada-pattern electrocardiographic changes, which contribute to a heightened risk of sudden cardiac death ( QT prolongation in HIV may be multifactorial, driven by chronic inflammation, ART effects, electrolyte imbalances, and direct myocardial involvement

Group 1 (15 rats) served as the control and group 2 (15 rats) underwent intermittent fasting (IF

References 1 Abdel-TawwabM.WafeekM

Similarly, mitophagy enhancers (e.g., urolithin A) and metabolic regulators (e.g., nicotinamide riboside, metformin) have shown promising activity in cellular and animal models, but their therapeutic effects in human PD (mitochondrial dysfunction evolving over decades) are largely unknown [135,136,137,138]

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