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For semiquantitative analysis, cells with positive signals in at least six random high-power fields (HPF) were visualized, counted, and expressed as the percentage of total DAPI-positive cells [32, 37]

Reasons for burning sensation in the feet: Damage to the peripheral nerves starts sending impulses to the brain, stimulating pain, tingling, or burning sensations in the feet

EurekAlert!, 2025, "Tirzepatide can produce clinically meaningful weight loss for at least 3 years in adults with overweight or obesity who don't have diabetes"

Individual variation : Same peptide affects people differently

Hence, it is likely that the different alterations reported in the gut microbiota of patients with BD can be partially involved in the differential production of histamine and in turn this may be related to the described effects