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Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

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These variable results both in experimental studies and in humans make it difficult to decide which models and experimental conditions are most relevant for the human pathophysiology in the context of steatosis and APAP hepatotoxicity

The fully developed phenotype of the homozygous Wobbler mouse shows a head tremor, a wobbly gait pattern, an inability to climb and an overall muscle atrophy as well as a reduced body size and weight compared to wild-type mice (Ott et al., 2015)

wild type (WT) was considered statistically significant