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PLoS One 9(10):e108694, 2014

There will be no or substantially no naturally associated substances such as nucleic acids

Patients may need to be reviewed each month or so during the initiation of a treatment, but this can become more infrequent once stabilised (perhaps every three to six months instead) 4

These reactions may deactivate a compound, activate a medication or create a reactive intermediate requiring rapid conjugation

Another constraint to the commercialization of nutraceuticals as a supporting therapy is the inability to formulate the phytocomponents in a suitable dosage form that can reach its targeted site