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This allows them to pass through the harsh environment of the stomach and be absorbed more efficiently

The phenotypic switch from M1 to reparative macrophages (M2) is critical for tissue regeneration (Finley et al., 2016

S2CID 1556558

Additionally, several other genes were identified as being implicated in this process, including metal-regulated transcription factor 1 (MTF1), glutaminase (GLS), cyclin-dependent kinase inhibitor 2A, HSP70, dihydrolipoamide branched-chain transacylase E2, SLC31A1, ATOX1, copper chaperone for cytochrome c oxidase 11, dihydrolipoamide S-succinyltransferase and transporters of copper and zinc 1 (ZnT1) (50-54)

To corroborate these findings on a functional level, we isolated activated ILC2s from IL-33 challenged BALB/c mice ( Figure 3A ), which were then incubated for 24h with either an MT1 agonist (Ramelteon), MT1 antagonist (S-26131), MT2 agonist (Tasimelteon), MT2 antagonist (4-P-PDOT) and/or melatonin ( Figures 3BE )