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KD is a lifelong treatment for some diseases, and therefore relatively low compliance rates (38% for CKD, 56% for MAD) were reported in a meta-analysis of 270 patients (12)

For in vitro cellular experiments, all analyses were independently repeated at least three times, with each treatment group including at least three independent culture wells

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This, in turn, may trigger inflammatory responses, promote epithelial-mesenchymal transition, impair tubular repair mechanisms, and contribute to the development of renal fibrosis