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Moreover, it is the only candidate drug for ALS to be independently validated by the ALS Therapy Development Institute (Soon et al., 2011)

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Taxier et al., 2022), TgF433-AD rats (Pentkowski et al., 2018), Wistar rats injected with intracerebroventricular streptozotocin to induce sporadic AD (Roy et al., 2022), and THY-Tau22 (which expresses human 4-repeat tau mutated at sites G272V and P301S under a Thy1.2-promotor) (Schindowski et al., 2006), also display increased anxiety-like behaviors