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Shao D, Oka SI, Liu T, Zhai P, Ago T, Sciarretta S, et al

Oxidative stress is one of the core pathological mechanisms of PD

It targets only the pigment without harming the surrounding skin when the proper protocols are observed

For LC-MS analysis, samples were thawed on ice-water bath, then 40 L of whole blood was injected into 450 L cold extraction solvent comprising of mixture of Acetonitrile:Methanol:Milli-Q water in ratio 40:40:20 according to protocol described in Presterud et al 35