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These findings demonstrate a mechanistic link between impaired protein degradation and metastatic progression, revealing the therapeutic potential of processes that cause controlled protein degradation in cancer

Early studies on TCR signaling demonstrated that a transient, tightly regulated burst of ROSgenerated by enzymes such as Duox1functions as a critical second messenger required for full T-cell activation [35, 36]

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EGCG, a compound with anti-aggregation properties, also plays a role in protein homeostasis by enhancing the unfolded protein response (UPR) and activating heat shock proteins

Medicine (Baltimore) 95: e2812