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Other advances have been realized by rational optimization of bNAb epitopes, resulting in increases in the breadth and potency of NAb responses elicited after immunization 23

The resulting two-phage cocktail effectively suppressed planktonic bacterial growth for up to seven days and significantly reduced biofilm biomass without the emergence of dual resistance

A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer

This study lacked a placebo control, so results should be interpreted cautiously

doi: 10.1128/MCB.23.22.8137-8151.2003 147 ZhangY.LuL.JiaJ.JiaL.GeulaC.PeiJ.et al