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The possible carcinogenic mechanisms involve an increase in oxidative stress, that may cause oxidative DNA damage, interfere with DNA repair systems, deregulate growth control mechanisms, and modify DNA methylation patterns ( Living in volcanic areas represents a further risk factor as some of the highest incidences of thyroid cancer are registered in volcanic regions ( Many heavy metals (As, Cd, Cr, Hg, and Pb) have never been tested yet as potential human thyroid carcinogens

In this environment, absorption of glucose is coupled to an electrochemical gradient

KPV operates differently

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