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L-carnitine may help target belly fat by boosting fat metabolism and energy production, particularly when paired with exercise

For example, co-administration of L-carnitine and -lipoic acid did not improve insulin resistance but markedly ameliorated mitochondrial ultrastructure and reduced serum liver enzyme levels, suggesting a preferential correction of mitochondrial injury ( / Leiden mice, only the combined intervention with nicotinamide riboside, rather than either monotherapy, significantly attenuated obesity and hepatic steatosis, accompanied by coordinated upregulation of genes involved in fatty acid oxidation and insulin signaling (61)

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Drugs Exp Clin Res 1992;18:355-365

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