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10.3389/fphar.2017.00432 20 ClarkJ

The extrinsic pathway is activated by the binding of a cell surface death receptor (such as FAS [Fas cell surface death receptor], TNFRSF1A/TNFR1 [TNF receptor superfamily member 1A], or TNFSF10/TRAIL [TNF superfamily member 10]) to its corresponding ligand, leading to CASP8 activation [97]

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Similar content being viewed by others Introduction Dimerization is essential in biological systems, playing a key role in regulating physiological functions and regulatory mechanisms of living organisms 1,2