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Conversely, pharmacological inhibition of FSP1 or DHODH can sensitize tumors to ferroptosis, especially in cancers with high FSP1 expression or reliance on mitochondrial metabolism, raising the possibility of synthetic lethality when combined with GPX4 inhibition

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Phase II study of a multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report

Finally, low glutamine in the core region of solid tumors led to histone hypermethylation due to decreased -ketoglutarate level, resulting in cell dedifferentiation and therapeutic resistance in melanoma cells [64]