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[7] The effects of high-dose NAD+ on a developing fetus or nursing infant have not been studied, so the therapy is avoided entirely in these situations out of caution

Instead, according to an older article, typical inflammation causes injection site reactions

Biochemical Pharmacology (NLM) .Read source (2021)

Apolipoprotein E gene polymorphism is related to metabolic abnormalities, but does not influence erythrocyte membrane lipid composition or sodium-lithium countertransport activity in essential hypertension