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doi: 10.1126/scitranslmed.ade6509 83 LinnerbauerM.WheelerM

The sirtuin family in health and disease

A classical hypothesis suggests that PAECs are damaged by various environmental factors, such as chronic hypoxia or shear stress, leading to massive apoptosis

ROS-generating regulator: NOX4 In 2001, Wautier and colleagues conducted a study on human endothelial cells and discovered that nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) serve as pivotal downstream effectors of the AGE-RAGE signaling pathway, connecting the AGE-RAGE axis to ROS production within the cellular milieu (Wautier et al