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This microenvironment is sustained by a dynamic cellular network involving Leydig cells, peritubular myoid cells (PMCs), and Sertoli cells (SCs), which collectively interact with spermatogonia to establish and maintain an optimal niche for spermatogonial stem cells (SSCs)

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Statements Author contributions YL: Writing original draft, Methodology

This dual action is considered significant for maintaining balance between extracellular breakdown and renewal