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In the pivotal, phase 3, placebo-controlled RESPONSE trial (NCT04620733), seladelpar, a novel delpar (selective PPAR-delta agonist), led to a significantly higher percentage of PBC patients achieving the composite biochemical endpoint (ALP 0 U/L from baseline) and safety by baseline ALP subgroup were also evaluated

However, in vivo studies yielded conflicting results, with eosinophils appearing to play protective (da Silva Marques et al, 2021

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For example, engineered immature dendritic cells (imDCs) in mice express a well-characterized exosomal membrane protein (Lamp2b) fused to v integrin-specific iRGD peptide (CRGDKGPDC)